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In recent years, as acupuncture has become a more commonplace in western culture, there has been a lot of research into how it works from a western medicine perspective.
We know for example that acupuncture points are in areas where there is a high density of free nerve endings, arterioles, lymphatic vessels and mast cells. We also know that acupuncture works through a series of interactions between the nervous system, the endocrine system and the immune system. There has also been studies showing the increase in beta-endorphins (pain relief pathway) and serotonin from acupuncture.
There are lots of papers and theories out there if you are interested in learning more.
What Acupuncture Can and Cannot Treat
The Validity of Acupuncture in Veterinary Medicine
Biophysical Characteristics of Meridians and Acupoints: A Systematic Review